For 11 straight years, San Beda has made it to the Final 4 while also clinching the twice-to-beat bonus.
The Red Lions are eyeing to reclaim the NCAA championship after yielding it last year.
But there is no clear path to a title and standing in the way of San Beda are three other teams also capable of winning it all.
No. 2 Arellano University has been formidable this season thanks to its star point guard Jio Jalalon. For the good part of the second round, the Chiefs were primed to finish the eliminations on top of the standings before the Red Lions beat them twice.
The Chiefs, though, are pitted against the dangerous Mapua Cardinals and their reigning MVP Allwell Oraeme in the semifinals.
Arellano swept Mapua in the elimination round with both games ending in blowouts.
In the other semis matchup, No. 4 University of Perpetual Help takes on San Beda.
The Lions held a 2-0 against the Altas in the eliminations.
The Final Four starts on Friday at Mall of Asia Arena.