The Lady Spikers, who secured second place with the win, banked on their experience to ward off the Lady Bulldogs, who have vastly improved this season.
Michelle Gumabao and MVP Abigail Maraño combined for 19 hits for La Salle, which finished the game in just 68 minutes.
“Our experience won it for us,” said head coach Ramil de Jesus as La Salle notched its fourth win in five outings.
Dindin Santiago was the lone Lady Bulldog who wound up with 12 hits, with scorers Myla Pablo and Aiko Urdas in the struggling end.
NU dropped to fifth place with its third consecutive loss in five matches.